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. 2016 Oct 19;6:35710. doi: 10.1038/srep35710

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Left-hand side: surface representation of monomers D (upper, in grey) and C (lower, in light-pink) with bound NAD⁺ and REA shown as green and yellow sticks, respectively. Right-hand side: a zoom-in showing the REA and NAD⁺ conformations as observed in monomers D and C, shown with a surface representation in the background, after optimal superposition; the catalytic C314 from monomer D is depicted as grey stick and the E280 is shown in the two conformations adopted in monomer D and C. The two conformations observed for REA and NAD⁺ are coupled as indicated by the arrows, one couple representing the closed state (in monomer D) and the open state (in monomer C) that represents the product-release conformation. The residue E280 also oscillates between two conformations following those observed for the ligands.