Table 1. Data collection and refinement statistics.

DATA COLLECTION
Space group	P21
Cell dimensions
a, b, c (Å)	82.7, 159.8, 177.6
β(°)	93.7
Resolution (Å)	47.51 - 2.9
Rpim/Rmerge	0.109(0.490)/0.184(0.785)
CC1/2	0.983 (0.534)
Mean(I)/sd(I)	5.4 (1.6)
Completeness (%)	98.3 (97.3)
Redundancy	3.6 (3.2)
REFINEMENT
Resolution (Å)	2.9
Total reflections	364578 (31677)
Unique reflections	100139 (9865)
Rwork/Rfree	0.2244/0.2869
No. atoms
Protein	29498
Water	63
Ligands	440
Mean B-factors
Protein (Å2)	42.3
Water (Å2)	16.1
All Ligands (Å2)	48
REA_C (Å2)	26
NAD_C (Å2)	19
REA_D (Å2)	24
NAD_D (Å2)	28
R.m.s deviations
Bond lengths (Å)	0.014
Bond angles (°)	1.48
Ramachandran statistics
Residues in favoured region (%)	95.6
Residues in allowed region (%)	4.0
Residues in outlier region (%)	0.3