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. 2016 Oct 19;6:35574. doi: 10.1038/srep35574

Figure 2. Enhanced insulin sensitivity in F13a1−/− mice fed on HFD.

Figure 2

(a) Insulin tolerance test (ITT) shows that F13a1−/− mice on HFD have similar insulin sensitivity as on chow, where as F13a1+/+ show insulin resistance on HFD. (b) AUC for ITT shows a significant protection from insulin resistance in F13a1−/− mice on HFD (n = 9–11 mice/group) (c–f) In vivo insulin signalling in metabolic tissues (epididymal fat, inguinal fat, skeletal muscle and liver) of F13a1−/− and F13a1+/+ mice. Mice were fasted for 6 h, and injected with saline (S) or insulin (Ins) (2.5 U/kg). Tissues were dissected immediately and total protein extracts were prepared and analyzed by Western blotting for p-Akt (S473), total Akt levels and insulin receptor (IRβ). All error bars represent SEM; (n = 3 mice/group); *p < 0.05; **p < 0.01; N.S.-Not Significant.