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. 2016 Oct 19;6:35592. doi: 10.1038/srep35592

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Mice hemizygous for GLT1-GFP and heterozygous for Slc7a10 show beta-galactosidase expression exclusively in GFP-positive astrocytes in the spinal cord (a–c, SC), brainstem, (d–f, BS), cerebellum (g–i, CBM), cortex (j–l, CTX), and hippocampus (m–o, HIPP). Significantly higher densities of beta-galactosidase-positive astrocytes are observed in the spinal cord compared to all other brain regions examined (p < 0.001), and significantly higher densities are present in the brainstem compared to cortex and hippocampus (p < 0.001) (p). Similarly, the percentage of beta-galactosidase-expressing astrocytes is significantly higher in spinal cord and brainstem compared to cortex and hippocampus (p < 0.001) (q). Orthogonal views are shown for each region, demonstrating colocalization of GFP and beta-galactosidase signals. n = 3 biological replicates for each genotype. Scale bar, 50 μm.