Figure 1.

Biological inspiration. Ability to directly interrogate on-target redox responses in vivo promises to advance a mechanistic understanding of specific redox pathways and precision therapeutic intervention. RES/ROS, reactive electrophilic/oxygen species. “SH” designates a thiol group of the cysteine residue on the target sensor protein. “R” represents a generic chemical modification. Inset: representative natural and synthetic reactive small electrophilic signaling mediators and their associated bioactivities. Blue shades within the chemical structures highlight electrophilic motifs.