Figure 5. Increased intracellular Ca²⁺levels do not affect glomerular filtration or ex vivo kidney perfusion.

(A) Transcutaneous GFR measurement with hM₃D-expressing animals in comparison to their littermate controls does not reveal changes after CNO (5 mg/kg bodyweight) administration. Displayed are means (n = 4: hM3D positive, n = 3: hM3D negative). (B) Ex vivo kidney perfusion was performed with increasing CNO concentrations. Comparing hM₃D-expressing mice with their control littermates does not show differences in the vascular resistance. Angiotensin II was used as positive control. Displayed are means with standard error of the mean (SEM).