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Simplified model showing key elements of the swelling response in which activation of TRPV4 channels causes connexin hemichannels in the epithelium to open. This allows release of ATP that stimulates P2Y purinergic receptors. Then, SFKs are activated and Na,K-ATPase activity increases. The hemichannel opening—ATP release step, is a must. The response is abolished by hydrolysis of released ATP or blockade of either TRPV4 or hemichannels. SFKs, Src family tyrosine kinases.
