FIG 3 .

Strong parallelism in mutated genes defines adaptations to the environment of CF patient lungs. (A) Observed and expected numbers of genes with at least m mutations given the number of total mutations found. Genes with multiple mutations are in significant excess (P < 0.005). (B) Heatmap of mutation frequencies in the 10 loci that acquired ≥3 mutations, including point mutations upstream of the coding sequence that might be relevant for gene expression. Isolates are clustered by clade. (Right) Total numbers of mutations acquired per gene (m) and the type of mutation (coding sequence [CDS] or intergenic [INT]).