Table 5.
Crude incidence, odds ratio, population attributable risk and population attributable fraction of preeclampsia and/or fetal growth restriction (FGR) in the population studied after excluding subjects with spontaneous abortions
| Preeclampsia | Crude incidence (%) 95 % CI | Odds ratio (95 % CI) | PAR (%) 95 % CI | PAF (95 % CI) |
|---|---|---|---|---|
| Controls/overall incidence* (n = 594) | 3.2 (1.9–5) | Reference | 6.5 (5.1–8.1)* | |
| Major rheumatic diseases (n = 67) | 26.9 (16.8–39.1) | 9.2 (4.3–19.5) | 1.4 (0.6–2.1) | 0.22 (0.09–0.33) |
| UCTD (n = 131) | 13.7 (8.4–20.8) | 4.6 (2.3–9.2) | 1.4 (0.6–2.1) | 0.21 (0.1–0.31) |
| Overall rheumatic diseases (n = 198) | 16.7 (11.8–22.6) | 6 (3.3–10.9) | 2.8 (1.7–3.9) | 0.43 (0.26–0.56) |
| No criteria for diagnosis (n = 150) | 6 (2.8–11.1) | 2 (0.9–4.6) | 0.05 (−0.01–1.1) | 0.07 (−0.03–0.17) |
| Fetal growth restriction (FGR) | ||||
| Controls/overall incidence* | 4.2 (2.8–6.1) | Reference | 8.8 (7.2–10.8)* | |
| Major rheumatic diseases | 26.9 (16.8–39.1) | 8.8 (4.4–17.3) | 1.6 (0.9–2.4) | 0.18 (0.1–0.26) |
| UCTD | 16 (10.2–23.5) | 4.1 (2.2–7.8) | 1.5 (0.06–2.4) | 0.17 (0.07–0.26) |
| Overall rheumatic diseases | 19.7 (14.4–25.9) | 5.5 (3.2–9.5) | 3.1 (1.9–4.3) | 0.36 (0.22–0.47) |
| No criteria for diagnosis | 13.4 (8.4–20) | 3.6 (1.9–6.7) | 1.4 (0.05–2.3) | 0.16 (0.06–0.26) |
| Preeclampsia or FGR | ||||
| Controls/overall incidence* | 6.1 (4.3–8.3) | Reference | 11.5 (9.6–13.5)* | |
| Major rheumatic diseases | 29.9 (19.3–42.3) | 6.8 (3.6–12.9) | 1.7 (0.09–2.5) | 0.15 (0.08–0.21) |
| UCTD | 22.9 (16–31.1) | 4.4 (2.5–7.5) | 2.2 (1.1–3.2) | 0.19 (0.1–0.27) |
| Overall rheumatic diseases | 25.3 (19.4–31.9) | 5.1 (3.2–8.3) | 3.9 (2.6–9.6) | 0.34 (0.22–0.44) |
| No criteria for diagnosis | 14.8 (9.5–21.5) | 2.7 (1.5–4.8) | 1.4 (0.4–2.3) | 0.1 (0.04–0.2) |
UCTD undifferentiated connective tissue disease
Odds ratios (OR), population attributable risk (PAR) and population attributable fraction obtained by logistic regression analysis containing preeclampsia and/or FGR as outcomes and category of rheumatic disorders (controls, major rheumatic diseases, UCTD, no criteria for diagnosis), nulliparity (yes, no), first trimester smoking (yes, no), chronic hypertension (yes, no) and previous low birthweight (<2500 g) infant (yes, no) as explanatory variables. The analysis was carried out in 941 viable pregnancies
*Overall incidence