1.

(A) Decay-corrected whole-body coronal positron electron tomographic images of nude mice bearing human U87MG tumor at 1, 4, and 21 h after injection of 3.7 MBq of ⁶⁴Cu-DOTA-IO, ⁶⁴Cu-DOTA-IO-RGD, or ⁶⁴Cu-DOTA-IO-RGD with 10 mg of c(RGDyK) peptide per kilogram (300 μg of iron-equivalent IO particles per mouse). (B) T2-weighted magnetic resonance images of nude mice bearing U87MG tumor before injection of IO nanoparticles (a, e) and at 4 h after tail-vein injection of DOTA-IO (b, f), DOTA-IO-RGD (c, g), and DOTA-IO-RGD with blocking dose of c(RGDyK) (d, h). Reproduced with permission from, Ref. 20. Copyright 2008 Society of Nuclear Medicine and Molecular Imaging. (C) Representative whole-body coronal positron electron tomographic images of U87MG tumor-bearing mice at 2, 6, 18, 24, and 48 h after intravenous (IV) injection of 100 μL (50 μg, 300 μCi) of ⁶⁴CuCl ₂, GSH-[ ⁶⁴Cu]CIS/ZnS, and PEGylated GSH-[ ⁶⁴Cu]CIS/ZnS RQDs (3 mice per group). (D) CRET images of U87MG tumor-bearing mice at 6 h after injection of 100 μL (300 μCi) of ⁶⁴CuCl ₂, GSH-[ ⁶⁴Cu]CIS/ZnS, and PEGylated GSH-[ ⁶⁴Cu]CIS/ZnS RQDs, respectively. Circle, tumor area (3 mice per group). These luminescence images were acquired without excitation light with open and red filter (>590 nm). Reproduced with permission from Ref. 21. Copyright 2014 American Chemical Society.