3.

(A) Three-dimensional maximum intensity projection images (anterior view) of a healthy New Zealand white rabbit (3 kg) obtained in CT (120 kV, 200 mA) and MR (3D FSPGR sequence, TR/TE=9.8/4.3) prior to and after IV administration (as indicated) of the liposome formulation of iohexol and gadoteridol. Reproduced with permission from Ref. 30. Copyright 2007 Springer. (B) In vivo PA images (a) and PA signal intensities (c) of the tumorous area recorded at 0, 2, 6, and 24 h after IV injection of Bi ₂S ₃ NPs into mice bearing 4 T1 tumors (dosage: 200 μL of Bi ₂S ₃ NPs solution containing 0.5 mg Bi). In vivo CT images (b) and signal intensities (d) of the tumorous area of another group of tumor-bearing mice recorded at 0, 2, 6, and 24 h after IV injection of Bi ₂S ₃ NPs (dosage: 200 μL of Bi ₂S ₃ NPs containing 1 mg Bi). The tumor site is pointed by red arrows. e: Infrared thermal images of tumor-bearing mice recorded during laser irradiation. f: H&E staining of tumor tissues harvested from the different groups of mice. Reproduced with permission from Ref. 33. Copyright 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.