2.

Key differences in preoperative and postoperative RT

Item	Preoperative RT	Postoperative RT
Dose	Lower dose (50 Gy)	Higher dose (60-66 Gy)
Treatment volume	Smaller treatment volume	Larger treatment volume
Rate of would complications	More acute wound complications (35%)	Wound complications up to 17%
Features	Offers the possibility to perform translational research on the clinicopathological behaviour of individual sarcoma subtypes to RT	Increase late RT toxicities:increased fibrosisincreased edemaincreased joint stiffness
		Rarely, may provide the option of omission of RT when adequate margins are achieved. Ideally this should be discussed in a multidisciplinary meeting