Table 2.
Associations of SNPs with CRC risk in the discovery stage, replication stage and combined samples
| Gene | SNP | Chr | Position (hg19) | Genotype | Effect allele | Discovery stage | Replication stage | Combined | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case/control | OR (95 % CI)a | P a | Case/control | OR (95 % CI)a | P a | Case/control | OR (95 % CI)a | P a | ||||||
| NFKBIA | rs1022714 | 14 | 35871407 | GG | A | 550/450 | 0.78 (0.67–0.92) | 0.003 0.045* |
291/293 | 1.12 (0.90–1.41) | 0.306 | |||
| GA | 359/362 | 191/200 | ||||||||||||
| AA | 43/63 | 27/37 | ||||||||||||
| NFKBIE | rs2282151 | 6 | 44226195 | TT | C | 329/352 | 1.24 (1.08–1.42) | 0.003 0.034* |
136/202 | 1.39 (1.14–1.70) | 0.001 | 465/554 | 1.30 (1.16–1.46) | 8.9E-6 |
| TC | 456/401 | 281/251 | 737/652 | |||||||||||
| CC | 159/118 | 91/72 | 250/190 | |||||||||||
Abbreviation: Chr chromosome, OR odds ratio, 95 % CI 95%confidence interval
aLogistic regression were performed in additive model, adjusted for age and sex
* P-value after FDR control