Table 3.
Age-stratified analyses of rs2282151 with CRC risk in the discovery, replication stage and combined samples
| Discovery stage | Replication stage | Combined | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Case/control | OR (95 % CI) | P a | Case/control | OR (95 % CI) | P a | Case/control | OR (95 % CI) | P a | |
| Age < 50 | 158/246 | 1.39 (1.03, 1.88) | 0.029 | 151/390 | 1.28 (0.97, 1.68) | 0.080 | 309/636 | 1.33 (1.09, 1.62) | 0.006 |
| 50 ≤ Age < 70 | 520/552 | 1.24 (1.04, 1.48) | 0.015 | 342/143 | 1.71 (1.22, 2.39) | 0.002 | 862/695 | 1.33 (1.14, 1.55) | 5.2E-4 |
| Age ≥ 70 | 274/77 | 1.00 (0.68, 1.47) | 0.992 | 24/16 | 4.48 (1.43, 14.02) | 0.010 | 298/93 | 1.17 (0.81, 1.68) | 0.405 |
| Combined | 952/875 | 1.24 (1.07, 1.42) | 0.003 | 517/549 | 1.49 (1.21, 1.84) | 1.8E-4 | 1469/1424 | 1.31 (1.17, 1.47) | 6.2E-6 |
Abbreviation: OR odds ratio, 95 % CI 95 % confidence interval
aLogistic regression were performed in additive model, adjusted for age and sex