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. 2016 May 17;6(5):e810. doi: 10.1038/tp.2016.80

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Posterior ventromedial prefrontal cortex (pVMPFC) connectivity in relation to anhedonia in patients with major depressive disorder (MDD). (a) Anhedonia was negatively correlated with pVMPFC connectivity during pleasant music listening, but not at rest, in reward- and emotion-related regions including left nucleus accumbens (NAc), left ventral tegmental area/substantia nigra (VTA/SN), left orbitofrontal cortex (OFC) and right mid-insula. (b) Anhedonia was also negatively correlated with pVMPFC connectivity during pleasant music listening, but not at rest, with fronto-temporal areas involved in music and speech processing including right middle temporal gyrus/superior temporal sulcus (MTG/STS) and right inferior frontal gyrus (IFG) pars opercularis.