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. 2016 May 10;6(5):e806. doi: 10.1038/tp.2016.66

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Copyright © 2016 Macmillan Publishers Limited

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Genetic deletion of Fgf14 reduces gamma frequency and affects working memory. (a) Representative traces of 10-s in vivo electroencephalogram recordings in the CA1 region of hippocampus (local field potential; LFP) in Fgf14^+/+ (left) and Fgf14^−/− mice (right); filtered traces within low- and high-gamma band are also shown. (b) Spectrogram analysis of the above-mentioned traces in the gamma range (30–100 Hz). (c) Mean power spectral density of CA1 activity showing a marked decrease in gamma power in Fgf14^−/− (n=7) with respect to Fgf14^+/+ (n=7) mice, as revealed by power analysis within both low- and high gamma (d). (e) Fgf14^−/− mice required a longer time to perform the eight-arm maze test (n=20 wild type and n=19 Fgf14^−/−; P<0.001, t-test). (f) Analysis of working memory errors committed during the test day showed a significant difference between genotypes (P<0.05, t-test). Data are expressed as mean±s.e.m. *P<0.05.