Balanced dopaminergic (DAergic) effects on parietal activation. (a)
Statistical significance (t-score) maps for multiple linear regression
(MLR) slopes demonstrating the linear associations across subjects between average
non-displaceable binding potential (BPND) measures in caudate (CD) and
ventral striatum (VS) and brain activation responses in the superior parietal
cortex (SPC; red-yellow pattern) and precuneus (blue-green pattern) during visual
attention for rested wakefulness (RW) and for sleep deprivation (SD; conjunction
analysis), superimposed on three orthogonal views of the human brain. Significance
threshold: PFWE<0.002, cluster corrected for multiple
comparisons in the whole brain. (b) Scatter plots showing the linear
associations between the predicted signals (BPNDVS and
BPNDCD; see the 'Methods' section) in SPC and
precuneus and the corresponding BPND measures in CD and VS. (c)
BPND correlation matrix showing the Pearson correlation factors (R;
computed across subjects) between average D2/D3R
measures in VS, CD, putamen (PU) and globus pallidus (GP), for RW and for SD
conditions. Sample size: 14 healthy, non-smoking, right-handed men. FWE,
family-wise error; κ, condition number; VIF, variance inflation factor.