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. 2016 May 31;6(5):e828. doi: 10.1038/tp.2016.93

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Copyright © 2016 Macmillan Publishers Limited

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Balanced dopaminergic (DAergic) effects on prefrontal activation. (a) Statistical significance (t-score) maps for multiple regression analysis (MLR) slopes demonstrating the negative linear associations across subjects between average non-displaceable binding potential (BP_ND) measures in putamen (PU) and ventral striatum (VS) and brain activation responses in the supplementary motor area (SMA; blue-green pattern) during visual attention for rested wakefulness (RW) and for sleep deprivation (SD; conjunction analysis), superimposed on three orthogonal views of the human brain. Significance threshold: P_FWE<0.005, cluster corrected for multiple comparisons in the whole brain. (b) Scatter plots showing the linear associations between the predicted signals (BP_ND^VS and BP_ND^PU; see the 'Methods' section) in SMA and the corresponding BP_ND measures in PU and VS.