Table 3. Frontal–subcortical connectivity and insula–mPFC connectivity in the two groups.

	NC	Depression	P-value
l_middle_frontal_gyrus
l_hippocampus_amygdala	0.69±0.29	0.34±0.22	0.000
r_hippocampus_amygdala	0.61±0.26	0.28±0.17	0.000
r_middle_frontal_gyrus
l_hippocampus_amygdala	0.62±0.26	0.35±0.14	0.000
r_hippocampus_amygdala	0.57±0.23	0.25±0.18	0.000
medial prefrontal cortex
l_insula	0.02±0.26	0.25±0.22	0.003
r_insula	0.05±0.28	0.14±0.22	0.15

Abbreviation: NC, normal control.

Ten comparisons had been made, and the threshold for significance is set at P=0.005.