Table 3. Region of interest analyses showing significant treatment effects.
| Contrast | L/R | CS | x | y | z | T | Z | Brain region |
|---|---|---|---|---|---|---|---|---|
| Raloxifene > placebo | L | 86 | −44 | −48 | 4 | 5.80a | 4.35 | Inferior frontal gyrus |
| R | 36 | 34 | −14 | −24 | 4.71a | 3.79 | Hippocampus | |
| Placebo > raloxifene | None |
Abbreviations: CS, cluster size; L, left hemisphere; R, right hemisphere; T, t-value; Z, z-value.
a
Small volume family-wise error corrected, P<0.05.
Significant activation differences in the hippocampus and inferior frontal gyrus following raloxifene treatment compared with placebo. Centers of activation clusters are given by Montreal Neurological Institute stereotactic coordinates (x, y, z).