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. 2016 Oct 19;15:66. doi: 10.1186/s12943-016-0548-9

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Origin of 34 genes selected in the optimized prediction model. Initially, genes were included in the 422-gene signature because of their differential gene expression (red), miRNA expression (pink), DNA methylation (blue), or copy number variation (green) between CR and IR. Some genes had more than one biological difference