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. 2016 Oct 19;9:90. doi: 10.1186/s13041-016-0269-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — 5b (novel blocker of ASICs) suppresses inward GABAergic currents in ‘HEPES 2’ solution. In the same series of experiments during each sweep evoked PSCs were recorded below their reversal potential as inward currents (a), and above the reversal potential, as outward ones (b) - see Methods for details. Superimposed traces of original current traces (averages of 10 sequential PSCs) before (solid lines) and after (dotted lines) 5b (1 μM) application are shown on the right panel, summary graphs (n = 8) are shown on the left panel. PSC-amplitudes were normalized to control values (average of 20 PSCs preceding drug application). In control, absolute amplitudes of inward and outward currents (mean ± S.D) in this series of experiments were: -194.35 ± 93,1 pA; 214.8 ± 175.4 pA