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. 2016 Oct 18;16:215. doi: 10.1186/s12862-016-0790-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — WebLogo representation of the key sequence elements of the Cdc48 family. Sequence logos were generated from alignments of the D-domains of different Cdc48 family members using the WebLogo software [119]. Alignment contained more than 500 eukaryotes. The key regions involved in nucleotide binding and hydrolysis and the pore loop as defined by [13, 14, 18] are shown. The overall height of a stack indicates the sequence conservation at a certain position; the height of the symbols within the stack indicates the relative frequency of each amino acid at that position. The sequence logo of the entire alignment is provided in Additional file 12: Figue S8