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. 2016 Aug 22;1(4):e000072. doi: 10.1136/esmoopen-2016-000072

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Progesterone receptor (PR)A and PRB isoform receptor domains and post-translational modifications. PRs exist as either A (97 kDa) or B (120 kDa) translated from the same gene by the use of alternate promoters. Each isoform contains a C-terminal ligand-binding domain (LBD), a DNA-binding domain (DBD) and at least two transcriptional activation function (AF) domains. AF1 and AF2 are located within the aminoterminal domain (ATD) and the LBD, respectively. PRB contains an additional AF (AF3) within the unique 164-amino acid B-upstream segment. Adapted from Lange;13 Hill KK, et al.14