Table 1.
Reported gene fusions involving NTRK genes along with the corresponding tumour
| Gene fusion | Cancer type | Authors (year) |
|---|---|---|
| NTRK1 | ||
| LMNA-NTRK1 | Colorectal | Sartore-Bianchi et al (2016) |
| Soft tissue sarcoma | Doebele et al (2015) | |
| Spitzoid melanomas | Wiesner et al (2014) | |
| AYA sarcoma | Morosini et al (2015) | |
| Congenital infantile fibrosarcoma | Wong et al (2015) | |
| TPM3-NTRK1 | Colorectal | Lee et al (2015), Créancier et al (2015), Ardini et al (2014) |
| Papillary thyroid carcinomas | Bongarzone et al (1989), Butti et al (1995) | |
| Glioblastoma | Wu et al (2014) | |
| SQSTM1-NTRK1 | NSCLC | Farago et al (2015) |
| NTRK1-SQSTM1 | NSCLC | Siena et al (2015) |
| NFASC-NTRK1 | Glioblastoma multiforme | Frattini et al (2013), Kim et al (2014) |
| BCAN-NTRK1 | Glioblastoma multiforme | Kim et al (2014), Frattini et al (2013) |
| PPL-NTRK1 | Thyroid carcinoma | Farago et al (2015) |
| RFWD2-NTRK1 | Large cell neuroendocrine tumour (lung) | Fernandez-Cuesta et al (2014) |
| CD74-NTRK1 | Lung adenocarcinomas | Vaishnavi et al (2013) |
| MPRIP-NTRK1 | Lung adenocarcinomas | Vaishnavi et al (2013) |
| RABGAP1L-NTRK1 | ICC | Ross et al (2014) |
| TFG-NTRK1 | Thyroid carcinomas | Greco et al (1995) |
| TP53-NTRK1 | Spitzoid melanomas | Wiesner et al (2014) |
| NTRK2 | ||
| Unknown-NTRK1 | Appendiceal adenocarcinoma | Braghiroli et al (2016) |
| AFAP1-NTRK2 | Low-grade glioma | Stransky et al (2014) |
| AGBL4-NTRK2 | Glioblastoma | Wu et al (2014) |
| NACC2-NTRK2 | Pilocytic astrocytomas | Jones et al (2013) |
| PAN3-NTRK2 | Head and neck squamous cell carcinoma | Wu et al (2014) |
| QKI-NTRK2 | Pilocytic astrocytomas | Jones et al (2013) |
| TRIM24-NTRK2 | Lung adenocarcinoma | Wu et al (2014) |
| VCL-NTRK2 | Glioblastoma | Wu et al (2014) |
| NTRK3 | ||
| ETV6-NTRK3 | Glioblastoma | Zhang et al (2013) |
| Glioblastoma | Wu et al (2014) | |
| MASC | Tognon et al (2002), Ito et al (2015), Del Castillo et al (2015) | |
| Ductal carcinoma | Makretsov et al (2004), Arce et al (2005), Lagree et al (2011), Pinto et al (2014) | |
| Fibrosarcoma | Morerio et al (2004), Punnett et al (2000) | |
| Congenital mesoblastic nephroma | Watanabe et al (2002) | |
| Radiation-associated thyroid cancer | Leeman-Neill et al (2014) | |
| AML | Kralik et al (2011), Eguchi et al (1999), Knezevich et al (1998) | |
| GIST | Brenca et al (2015) | |
| MASC of salivary gland | Urano et al (2015), Skàlovà et al (2015) | |
| Papillary thyroid cancer | Leeman-Neill et al (2014), Seungbok Lee et al (2014) | |
| Colorectal | Hechtman et al (2015) | |
| BTBD1-NTRK3 | Glioblastoma | Wu et al (2014) |
AFAP1, actin filament-associated protein 1; AGBL4, ATP/GTP-binding protein-like 4; AML, acute myeloid leukaemia; AYA, adolescents and young adults; BCAN, brevican; BTBD1, BTB (POZ) domain containing 1; CD74, CD74 molecule; ETV6, ets variant 6; GIST, gastrointestinal stromal tumor; ICC, intrahepatic cholangiocarcinoma; LMNA, lamin A/C; MASC, mammary secretory breast carcinoma; MPRIP, myosin phosphatase Rho interacting protein; NACC2, NACC family member 2, BEN and BTB (POZ) domain containing; NFASC, neurofascin; NSCLC, non-small cell lung cancer; PAN3, PAN3 poly(A) specific ribonuclease subunit; PPL, periplakin; QKI, KH domain containing RNA binding; RABGAP1L, RAB GTPase activating protein 1-like; RFWD2, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; SQSTM1, sequestosome 1; TFG, TRK-fused gene; TP53, tumour protein p53; TPM3, tropomyosin 3; TRIM24, tripartite motif containing 24; VCL, vinculin.