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Sensitivity of the MLPA test
| BRCA1 mutation | BRCA1 methylation | BRCA1 mutation/methylation | |
|---|---|---|---|
| Total | 18 | 22 | 40 |
| BRCA1-like (≥0.5) | 15 | 20 | 35 |
| False negative | 3 | 2 | 5 |
| Sensitivity (%) | 83 | 91 | 87.5 |
BRCA1-like classification with cut-off value ≥ 0.5, non-BRCA1-like classification with cut-off value < 0.5
