Table 4.
Association of the BRCA1-like profile with biological parameters
| Variable | Valid cases | MLPA data | p-value | |
|---|---|---|---|---|
| (n) | BRCA1-like | Non-BRCA1-like | ||
| Total | 144 | 63 | 81 | |
| BRCA1 aberrations | 140 | <0.000001* | ||
| Wildtype | 100 | 28 | 72 | |
| Mutation/methylation | 40 | 35 | 5 | |
| T-cell assessment (CD3) | 53 | 0.458 | ||
| 0 | 17 | 7 | 10 | |
| 1+ | 16 | 7 | 9 | |
| 2+ | 20 | 12 | 8 | |
| PARP1 expression | 52 | 0.087 | ||
| 0–2+ | 38 | 17 | 21 | |
| 3+ | 14 | 10 | 4 | |
BRCA1-like classification with cut-off value ≥ 0.5, non-BRCA1-like classification with cut-off value < 0.5
*statistically significant with chi square test