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. Author manuscript; available in PMC: 2017 Jan 11.
Published in final edited form as: Biomacromolecules. 2015 Dec 11;17(1):154–164. doi: 10.1021/acs.biomac.5b01280

Scheme 1.

Scheme 1

Proposed exchange model between polyplex bound forms and free RNA. As suggested by DLS, the ~12–40 nm particles represent the majority of polyplex population.