Skip to main content
. Author manuscript; available in PMC: 2016 Oct 19.
Published in final edited form as: Am J Psychiatry. 2015 Jul 2;172(11):1148–1159. doi: 10.1176/appi.ajp.2015.14081031

TABLE 5.

Effects of Previous Treatment on Tiagabine-Induced Change in [11C]flumazenil VT in the Healthy Comparison Group and the Antipsychotic-Naive and Antipsychotic-Exposed Schizophrenia Groups, and Group Comparisonsa

ΔVT (%)
 Comparisonsb
Healthy
Comparison
Group
(N=22)
 Antipsychotic-
Naive
Schizophrenia
Group (N=8)
 Antipsychotic-
Exposed
Schizophrenia
Group (N=9)
 Antipsychotic-
Exposed
Versus
Antipsychotic-
Naive Group
 Healthy
Comparison
Versus
Antipsychotic-
Exposed
Group
 Healthy
Comparison
Versus
Antipsychotic-
Naive Groupc
SubdivisionandComponent
Region of Interest		 Mean SD Mean SD Mean SD p p p
Association cortex 9.2 11.6 −0.26 7.51 11.31 11.76 0.03 0.66 0.04
  Dorsolateral
prefrontal cortex		 9.7 12.1 −0.19 7.39 12.07 12.41 0.03 0.62 0.04
  Orbital frontal cortex 9.0 12.2 −0.88 7.35 12.92 10.64 0.01 0.41 0.04
  Medial prefrontal
cortex		 9.1 11.0 0.17 8.05 8.48 10.90 0.10 0.90 0.05
  Anterior cingulated
cortex		 7.1 12.6 −0.28 9.01 5.85 11.04 0.23 0.80 0.14
Sensory cortex 9.1 11.0 −0.07 7.06 9.17 11.57 0.07 0.99 0.04
  Parietal cortex 9.4 11.1 −0.08 6.98 10.99 13.12 0.05 0.74 0.03
  Occipital cortex 8.3 11.1 0.03 7.47 7.95 10.38 0.09 0.94 0.06
Medial temporal lobe 9.0 12.9 −0.43 9.68 8.94 11.65 0.09 1.00 0.07
  Amygdala 9.1 13.3 −0.54 12.05 6.74 11.63 0.22 0.64 0.08
  Hippocampus 9.3 15.3 −0.90 11.64 7.73 14.94 0.21 0.80 0.10
  Entorhinal cortex 8.3 14.2 0.41 10.58 12.01 10.47 0.04 0.49 0.16
  Parahippocampus 8.8 12.4 −0.08 8.71 9.32 11.68 0.08 0.92 0.07
a

VT=tissue distribution volume.

b

The p values are based on unpaired t tests.

c

Repeated-measures analysis of variance reached significance only for the comparison of the healthy comparison group and the antipsychotic-naive group.