Figure 3.
Full-length structures of Hsp90. The NTD is shown in blue, the MD in green and the CTD in brown. The second monomer of the biological dimer is shown in grey. In all structures exposed hydrophobic surfaces are highlighted in purple. A) Surface representations of the apo and ADP HtpG structure (Shiau et al., 2006); 2IOQ and 2IOP) and the yeast AMPPNP-bound structure (Ali et al., 2006). B) Surface representations of the apo HtpG solution state (Krukenberg et al., 2008) and the Grp94 crystal structure (Dollins et al., 2007).