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. Author manuscript; available in PMC: 2016 Oct 19.
Published in final edited form as: Q Rev Biophys. 2011 Mar 18;44(2):229–255. doi: 10.1017/S0033583510000314

Figure 4.

Figure 4

Variation in the N-terminal domain of Hsp90 occurs mostly in the lid. All structures are of the N-terminal domain of Hsp90 with the lid highlighted in red or blue. A) Two conformations of the isolated hHsp90 NTD (1YER and 1YES). In one conformation (blue) loop 2 (L2) extends into the nucleotide binding pocket. Large motions in the lid can also be seen in B) the NTD from the full length yeast structure (2CG9), and C) the isolated NTD of Grp94 bound to ADP (1TBW). D) Three additional lid conformations are observed in crystals of HtpG (2IOR, 2IOQ, and 2IOP).

HHS Vulnerability Disclosure