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Proposed chaperone cycles for the activation of the progesterone receptor and the Chk1 kinase. The progesterone receptor (PR) or Chk1 are first bound by Hsp40 followed by recruitment to Hsp70. Next, a complex with Hsp90, Hop, and Hsp70 forms. This intermediate complex also includes the kinase-specific p50 in the case of Chk1. The mature complex is then formed when Hsp70 and Hop dissociate. The mature complex for PR requires the binding of the additional factor, p23.
