Table 4. Association Between SNPs and Risk of HBV Breakthrough Infection in Children Born to HBsAg (+) Mothers.
| Gene | SNP | Genotype | Cases, % | Controls, % | Crude OR (95% CI) | P Value | Adjusted OR (95% CI)a | P Valuea |
|---|---|---|---|---|---|---|---|---|
| HLA-DPA1 | rs3077 | |||||||
| AA | 42 (46.7) | 64 (49.6) | 1 | 1 | ||||
| GA | 0 (0) | 9 (7.0) | - | 0.025 | 0.999 | |||
| GG | 48 (53.3) | 56 (43.4) | 1.306 (0.755 - 2.259) | 0.339 | 1.305(0.750 - 2.271) | 0.346 | ||
| A | 84 (46.7) | 137 (53.1) | 1 | |||||
| G | 96 (53.3) | 121 (46.9) | 1.294 (0.884 - 1.895) | 0.185 | ||||
| HLA-DPB1 | rs2281388 | |||||||
| GG | 26 (28.9) | 39 (30.2) | 1 | 1 | ||||
| GA | 49 (54.4) | 59 (45.7) | 1.246 (0.667 - 2.326) | 0.490 | 1.340(0.710 - 2.526) | 0.366 | ||
| AA | 15 (16.7) | 31 (24.0) | 0.726 (0.329 - 1.601) | 0.427 | 0.808(0.361 - 1.805) | 0.602 | ||
| G | 101 (56.1) | 137 (53.1) | 1 | |||||
| A | 79 (43.9) | 121 (46.9) | 0.886 (0.604 - 1.298) | 0.534 | ||||
| HLA-DPB1 | rs3135021 | |||||||
| GG | 61 (67.8) | 87 (68.0) | 1 | 1 | ||||
| GA | 25 (27.8) | 38 (29.7) | 0.938 (0.514 - 1.712) | 0.836 | 0.902(0.491 - 1.659) | 0.741 | ||
| AA | 4 (4.4) | 3 (2.3) | 1.902 (0.411 - 8.802) | 0.411 | 1.588(0.337 - 7.479) | 0.558 | ||
| G | 147 (81.7) | 212 (82.8) | 1 | |||||
| A | 33 (18.3) | 44 (17.2) | 1.082 (0.657 - 1.780) | 0.757 | ||||
| HLA-DPB1 | rs9277535 | |||||||
| AA | 46 (51.1) | 72 (54.5) | 1 | 1 | ||||
| GA | 1 (1.1) | 19 (14.4) | 0.082 (0.011 - 0.636) | 0.017 | 0.098(0.013 - 0.770) | 0.027 | ||
| GG | 43 (47.8) | 41 (31.1) | 1.642 (0.932 - 2.890) | 0.086 | 1.677(0.949 - 2.966) | 0.075 | ||
| A | 93 (51.7) | 163 (61.7) | 1 | |||||
| G | 87 (48.3) | 101 (38.3) | 1.510 (1.029 - 2.215) | 0.035 | ||||
| HLA-DPB2 | rs9366816 | |||||||
| TT | 19 (21.9) | 30 (23.3) | 1 | 1 | ||||
| TC | 55 (61.1) | 68 (52.7) | 1.277 (0.650 - 2.510) | 0.478 | 1.373(0.691 - 2.728) | 0.365 | ||
| CC | 16 (17.8) | 31 (24.0) | 0.815 (0.354 - 1.875) | 0.630 | 0.863(0.371 - 2.005) | 0.732 | ||
| T | 93 (51.7) | 128 (49.6) | 1 | |||||
| C | 87 (48.3) | 130 (50.4) | 0.921 (0.629 - 1.348) | 0.672 | ||||
| HLA-DQB1 | rs2856718 | |||||||
| TT | 55 (61.1) | 87 (67.4) | 1 | 1 | ||||
| TC | 23 (25.6) | 24 (18.6) | 1.516 (0.780 - 2.945) | 0.220 | 1.151(0.773 - 2.970) | 0.227 | ||
| CC | 12 (13.3) | 18 (14.0) | 1.055 (0.472 - 2.358) | 0.897 | 0.946(0.417 - 2.144) | 0.894 | ||
| T | 133 (73.9) | 198 (76.7) | 1 | |||||
| C | 47 (26.1) | 60 (23.3) | 1.166 (0.751 - 1.812) | 0.494 | ||||
| HLA-DQB2 | rs7453920 | |||||||
| GG | 75 (83.3) | 110 (84.0) | 1 | 1 | ||||
| GA | 14 (15.6) | 19 (14.5) | 1.081 (0.510 - 2.288) | 0.839 | 0.984(0.459 - 2.108) | 0.966 | ||
| AA | 1 (1.1) | 2 (1.5) | 0.733 (0.065 - 8.233) | 0.802 | 0.559(0.049 - 6.349) | 0.639 | ||
| G | 164 (91.1) | 239 (91.2) | 1 | |||||
| A | 16 (8.9) | 23 (8.8) | 1.014 (0.520 - 1.978) | 0.968 |
Abbreviation: CI, confidence interval; SNP, single nucleotide polymorphism; OR, odds ratio.
aThe P values and OR (95% CI) were calculated from logistic regression analyses adjusting for sex , age, HBV vaccination, HBIG treatment, delivery mode and feeding patterns.