Table A1.

Alternative Multivariable GCE Regression Results for Head and Neck Cancer Training Cohort

Characteristic	Cause-Specific Hazards (Cox Model), ω Ratio (95% CI)	Cause-Specific Hazards (Cox Model), ω+ Ratio (95% CI)	SDHRs (Fine-Gray Model), ω Ratio (95%CI)
Age at diagnosis, per year	0.99 (0.98 to 1.00)	0.99 (0.98 to 1.00)	0.98 (0.97 to 0.99)
Sex, ref: male
Female	1.20 (1.10 to 1.32)	1.35 (1.17 to 1.57)	1.26 (1.09 to 1.44)
Married, ref: no
Yes	1.02 (0.94 to 1.12)	1.03 (0.90 to 1.19)	1.10 (0.97 to 1.26)
Household income, ref: higher
Lower	0.97 (0.89 to 1.06)	0.96 (0.83 to 1.10)	0.94 (0.82 to 1.07)
Stage, ref: localized
Regional	1.39 (1.27 to 1.55)	1.66 (1.46 to 1.93)	1.21 (1.05 to 1.39)
Anatomic subsite, ref: oropharynx
Hypopharynx	1.10 (0.95 to 1.26)	1.19 (0.92 to 1.52)	1.02 (0.82 to 1.26)
Nasopharynx	1.34 (1.07 to 1.60)	1.77 (1.12 to 2.64)	1.29 (0.87 to 1.90)
Oral cavity	1.09 (0.98 to 1.21)	1.16 (0.97 to 1.38)	0.91 (0.78 to 1.07)
CCI, ref: 0
1	0.87 (0.79 to 0.96)	0.81 (0.69 to 0.94)	0.81 (0.700.94)
2	0.83 (0.73 to 0.94)	0.74 (0.60 to 0.91)	0.68 (0.56 to 0.83)
3	0.76 (0.61 to 0.93)	0.65 (0.47 to 0.89)	0.56 (0.41 to 0.76)
≥ 4	0.80 (0.63 to 0.98)	0.70 (0.49 to 0.98)	0.56 (0.41 to 0.76)
Postoperative RT, ref: no
Yes	0.84 (0.77 to 0.91)	0.76 (0.66 to 0.86)	0.92 (0.81 to 1.05)

NOTE. The data column on the left shows the estimate of the ω ratio for each covariate using the Cox model for cause-specific hazards. The middle data column shows the estimate of the ω⁺ ratio for each covariate using the Cox model for cause-specific hazards. The data column on the right shows the estimate of the ω ratio for each covariate using the Fine-Gray model for subdistribution hazards

Abbreviations: CCI, Charlson comorbidity index; GCE, generalized competing event; ref, reference; RT, radiation therapy; SDHR, subdistribution hazard ratio.