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. Author manuscript; available in PMC: 2017 Jan 13.
Published in final edited form as: Expert Rev Neurother. 2016 Jan 13;16(2):123–130. doi: 10.1586/14737175.2016.1134322

Figure 1. Schematic of seizure induction and drug treatment procedure.

Figure 1

Mice are pretreated with methylscopolamine and terbutaline (2 mg/kg each, i.p.) to minimize the peripheral effects of pilocarpine, and 30 min later, treated with pilocarpine (280 mg/kg, i.p.) to induce status epilepticus. The status epilepticus is allowed to persist for 1 h and terminated by pentobarbital (30 mg/kg, i.p.). Mice are then randomly split into groups and treated with vehicle or EP2 antagonist TG6-10-1 (5 mg/kg, i.p.) for multiple doses beginning hours after status epilepticus onset. Modified from Jiang et al., 2015.