Table 2.
Pharmacokinetic parameters for AmB after multiple dosing of Fungizone® and mAmB.
| Day | Formulation | AUC0−∞ (µg· hr/mL) |
CL (L/hr/kg) |
t1/2 (hr) |
Vd (L/kg) |
|---|---|---|---|---|---|
| 1 | Fungizone® (CV %) |
4.99 (4.04) |
0.200 (4.03) |
5.06 (3.59) |
1.17 (6.64) |
| mAmB (CV %) |
13.5 (2.94)** |
0.0741 (2.94)** |
7.38 (5.90) |
0.521 (5.47)* |
|
| 7 | Fungizone® (CV %) |
5.99 (3.65) |
0.167 (3.64) |
4.82 (4.01) |
1.03 (4.64) |
| mAmB (CV %) |
16.1 (2.31)** |
0.0623 (2.31)** |
8.02 (5.26) |
0.542 (4.21)* |
**
p<0.001 and
*
p<0.05 vs. Fungizone® group