Table 2a.
Association of heavy drinking with CD8+ T-cell subsets (linear and logistic regression)
| Outcome | T-cell distributionsb | Adjusted mean (%)difference in outcomes in heavy vs. non-heavy drinkers (95% CI) | ||
|---|---|---|---|---|
| Denominator | T-cell subset | Not Heavy Drinking | Heavy Drinking | |
| CD8+ | a CD8+ CD28- CD57+ | 34 (14) | 36 (15) | 2.38 (−2.00, 6.75) |
| CD8+CD45RO+CD45RA- (memory) | 34 (14) | 34 (14) | −1.13 (−5.14, 2.88) | |
| CD8+ CD45RO+CD45RA- (naïve) | 52 (14) | 53 (14) | 1.79 (−2.34, 5.91) | |
| CD8+ CD28- | 59 (11)* | 63 (13)* | 3.07 (−0.52, 6.65) | |
| CD8+ CD57+ | 40 (19) | 42 (20) | 2.10 (−3.76, 7.97) | |
| N Top Quartile of CD8+CD57+CD28- (%) | 20 (24%) | 34 (26%) | 1.17 (0.59, 2.34)c | |
| N (CD8 Naive / CD8 Memory) <1 (%) | 22 (27%) | 32 (24%) | 0.58 (0.28, 1.21)c | |
| CD8 Naive / CD8 Memory ratio | 2.33 (3.32) | 2.09 (2.03) | 1.03 (0.83, 1.28)d | |
| CD8+CD28- | CD8+ CD57+ | 56 (19) | 56 (20) | 0.94 (−4.78, 6.65) |
Adjusted for age, gender, hepatitis C, hepatitis B, herpes zoster, tuberculosis, cancer, past 30 day injection drug use
a
Pre-specified primary outcome. All other outcomes considered secondary or exploratory
b
Values are mean percentages (standard deviation) unless otherwise specified
c
Logistic regression results
d
Represents ratio of means (outcome was analyzed as log transformed variable)
*
p=0.03 for comparison of means by heavy drinking status