. Author manuscript; available in PMC: 2017 Aug 1.

Published in final edited form as: Alcohol Clin Exp Res. 2016 Jul 8;40(8):1737–1743. doi: 10.1111/acer.13142

Table 2b.

Association of heavy drinking with CD4+ T-cell subsets (linear and logistic regression)

Outcome		T-cell distributions^b		Adjusted Ratio of means for heavy vs. non-heavy drinkers (95% CI)
Denominator	T-cell subset	Not Heavy Drinking	Heavy Drinking
CD4+	^a CD4+CD28-CD57+	5.17 (10.69)	4.41 (5.89)	1.12 (0.69, 1.82)
	CD4+ CD45RO-CD45RA+ (memory)	52 (15)	54 (17)	1.70 (−3.05, 6.46)^c
	CD4+CD45RO+CD45RA- (naïve)	39 (15)	39 (16)	−0.29 (−4.68, 4.09)^c
	CD4+ CD28-	6.28 (12.24)	5.80 (7.04)	1.07 (0.71, 1.63)
	CD4+ CD57+	7.48 (11.05)	6.64 (6.54)	0.96 (0.69, 1.32)
	N Top Quartile of CD4+CD57+CD28- (%)	20 (24%)	34 (26%)	1.01 (0.49, 2.08)^d
	N (CD4 Naive / CD4 Memory) <1 (%)	52 (63%)	93 (71%)	1.33 (0.69, 2.58)^d
	CD4 Naive / CD4 Memory ratio	0.95 (0.79)	0.92 (0.87)	0.92 (0.72, 1.18)
CD4+CD28-	CD4+ CD57+	62 (31)	63 (29)	2.27 (−6.60, 11.13)^c

Adjusted for age, gender, hepatitis C, hepatitis B, herpes zoster, tuberculosis, cancer, past 30 day injection drug use

Pre-specified primary outcome. All other outcomes considered secondary or exploratory

Values are mean percentages (standard deviation) unless otherwise specified

Represents mean percent difference (outcome was analyzed as log transformed variable)

Logistic regression results