Table 2b.
Association of heavy drinking with CD4+ T-cell subsets (linear and logistic regression)
| Outcome | T-cell distributionsb | Adjusted Ratio of means for heavy vs. non-heavy drinkers (95% CI) | ||
|---|---|---|---|---|
| Denominator | T-cell subset | Not Heavy Drinking | Heavy Drinking | |
| CD4+ | a CD4+CD28-CD57+ | 5.17 (10.69) | 4.41 (5.89) | 1.12 (0.69, 1.82) |
| CD4+ CD45RO-CD45RA+ (memory) | 52 (15) | 54 (17) | 1.70 (−3.05, 6.46)c | |
| CD4+CD45RO+CD45RA- (naïve) | 39 (15) | 39 (16) | −0.29 (−4.68, 4.09)c | |
| CD4+ CD28- | 6.28 (12.24) | 5.80 (7.04) | 1.07 (0.71, 1.63) | |
| CD4+ CD57+ | 7.48 (11.05) | 6.64 (6.54) | 0.96 (0.69, 1.32) | |
| N Top Quartile of CD4+CD57+CD28- (%) | 20 (24%) | 34 (26%) | 1.01 (0.49, 2.08)d | |
| N (CD4 Naive / CD4 Memory) <1 (%) | 52 (63%) | 93 (71%) | 1.33 (0.69, 2.58)d | |
| CD4 Naive / CD4 Memory ratio | 0.95 (0.79) | 0.92 (0.87) | 0.92 (0.72, 1.18) | |
| CD4+CD28- | CD4+ CD57+ | 62 (31) | 63 (29) | 2.27 (−6.60, 11.13)c |
Adjusted for age, gender, hepatitis C, hepatitis B, herpes zoster, tuberculosis, cancer, past 30 day injection drug use
a
Pre-specified primary outcome. All other outcomes considered secondary or exploratory
b
Values are mean percentages (standard deviation) unless otherwise specified
c
Represents mean percent difference (outcome was analyzed as log transformed variable)
d
Logistic regression results