Table 3a.
Association between quantity and frequency of drinking with CD8+ T-cell subsets (linear regression)
| Denominator | T-cell subset (relative frequencies (%)unless otherwise specified) | Adjusted mean (%) difference by drinking days (Low tertile (0–8 days) is referent group) | Adjusted mean (%) difference by drinking volume (Low tertile (0–15.7g) is referent group) | ||
|---|---|---|---|---|---|
| Mid tertile (9–14 days) | High tertile (15–30 days) | Mid tertile (16.0–35.9g) | High tertile (39.0–449.5g) | ||
| CD8+ | a CD8+CD28-CD57+ | −0.72 (−5.97, 4.53) | 2.39 (−2.57, 7.35) | 5.53 (0.08, 10.98) | 2.44 (−2.42, 7.31) |
| CD8+CD45RO+CD45RA- (memory) | −1.03 (−5.84, 3.79) | −0.74 (−5.29, 3.81) | −0.39 (−5.41, 4.63) | −1.76 (−6.24, 2.73) | |
| CD8+CD45RO-CD45RA+ (naïve) | 1.43 (−3.52, 6.38) | 1.53 (−3.15, 6.21) | 1.90 (−3.26, 7.06) | 2.72 (−1.89, 7.33) | |
Analyses adjusted for age, gender, hepatitis C, chronic hepatitis B, herpes zoster, tuberculosis, injected drug use in the past 30 days, and cancer
a
Pre-specified primary outcome. All other outcomes considered secondary