Table 3b.
Association between quantity and frequency of drinking with CD4+ T-cell subsets (linear regression)
| Denominator | T-cell subset (relative frequencies (%)unless otherwise specified) | Adjusted mean (%) difference by drinking days (Low tertile (0–8 days) is referent group) | Adjusted mean (%) difference by drinking volume (Low tertile (0–15.7g) is referent group) | ||
|---|---|---|---|---|---|
| Mid tertile (9–14 days) | High tertile (15–30 days) | Mid tertile (16.0–35.9g) | High tertile (39.0–449.5g) | ||
| CD4+ | a CD4+CD28-CD57+ | 0.65b (0.36, 1.16) | 0.74b (0.43, 1.28) | 0.98b (0.48, 2.04) | 0.94b (0.49, 1.79) |
| CD4+CD45RO+CD45RA- (memory) | 2.64 (−3.05, 8.34) | 2.33 (−3.05, 7.71) | 2.92 (−3.03, 8.86) | 2.46 (−2.85, 7.77) | |
| CD4+CD45RO-CD45RA+ (naïve) | −1.06 (−6.32, 4.20) | −0.90 (−5.87, 4.07) | 0.00 (−5.50, 5.49) | −0.98 (−5.88, 3.93) | |
Analyses adjusted for age, gender, hepatitis C, chronic hepatitis B, herpes zoster, tuberculosis, injected drug use in the past 30 days, and cancer
a
Pre-specified primary outcome. All other outcomes considered secondary
b
Ratio of means (outcome was analyzed as a log transformed variable)