Fig 4. The most relevant network associated with DE genes of NP vs NN comparison.

Up-regulated (pink) and down-regulated (green) genes involved in lipid metabolism, small molecules biochemistry and Inflammatory response functions. Different shapes indicate different function of gene products: squares for cytokines, horizontal rectangles for ligand-dependent nuclear receptor, vertical rectangles for G-protein coupled receptors, vertical rhombus for enzymes, horizontal rhombus for peptidase, triangles for phosphatase, inverted triangle for kinase, vertical ovals for transmembrane receptors, horizontal ovals for transcription regulators, trapezius for transporters, double circles for complexes and circles for others.