Table 6. Top canonical pathways associated with DE genes in PP vs NN and NP vs NN comparisons.

Ingenuity Canonical Pathways	Molecules	DE gene set
Eicosanoid Signaling	ALOX15, LTC4S, ALOX5, CYSLTR2	PP vs NN
Leukotriene Biosynthesis	LTC4S, ALOX5	PP vs NN
G-Protein Coupled Receptor Signaling	P2RY14, ADORA3, CHRM3, ADRB3, PRKCG	PP vs NN
Granulocyte Adhesion and Diapedesis	VCAM1, IL1RL1, MMP14, HRH4	PP vs NN
Leukotriene Biosynthesis	LTA4H, LTC4S	NP vs NN
EIF2 Signaling	RPS15, RPS23, RPL26, RPL37	NP vs NN
Eicosanoid Signaling	LTA4H, LTC4S	NP vs NN
Tryptophan Degradation to 2-amino-3-carboxymuconate Semialdehyde	IDO1	NP vs NN