Table 2. Titration algorithm for IDegAsp or IGlar.

Pre-breakfast plasma glucose*		Adjustment
mmol/L	mg/dL	U
< 3.1†	< 56†	–4 (If dose > 45 U, reduce by 10%)
3.1–3.8†	56–69†	–2 (If dose > 45 U, reduce by 5%)
3.9–4.9	70–89	0
5.0–6.9	90–125	+2
7.0–7.9	126–143	+4
8.0–8.9	144–161	+6
≥ 9.0	≥ 162	+8

*Mean of three consecutive days’ measurements for dose increases; lowest value for dose decreases.

^†Unless there is an obvious explanation for the low value, such as a missed meal.

IDegIAsp, insulin degludec/insulin aspart; IGlar, insulin glargine (U100).