Fig 7. TIGR4 spxB mutant is not lethal in an IP mouse model.
BALB/c mice were infected IP with 1 x 103 cells and monitored for disease progression. Mice were infected with TIGR4 and the spxB, lctO, and double spxB-lctO mutants. Bacterial presence in the blood was determined at 24 hours (A) post infection. Survival of mice was followed for 8 days (B). For clarity purposes, the survival curves of TIGR4 and the lctO mutant was nudged. For blood titers, mutant strains were compared to wild type using nonparametric Mann-Whitney t test; ** p = 0.01–0.001. Survival data were analyzed using the Mantel-Cox log rank test. p = 0.0031 for TIGR4 spxB mutant compared to wild type; all other mutants compared to the wild type were non-significant.