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. 2015 Oct 28;24(7):985–991. doi: 10.1038/ejhg.2015.232

Figure 3.

Figure 3

Schematic representation of three ZEB1 deletions causing posterior polymorphous corneal dystrophy 3. The deletions identified in C17, C27, and B8 do not share any common breakpoints. A large deletion spanning ~3.3 Mb was identified in family C17. This mutation encompasses the entire ZEB1 gene and nine other protein coding genes. C27 had an ~71-kb deletion, which spans the 3' end of ZEB1 from intron 3 and a region downstream containing no additional genes. Proband B8 has a 0.8–1 Mb deletion encompassing the entire ZEB1 gene and at least partially encompasses the flanking gene ARHGAP12. All three deletions differ in size and position and do not share common breakpoints (grey bar: deleted region, white bar: unknown region).