Table 2.
Clinical characteristics of children (n=275) aged 5 – 18 years whose medical records were analyzed, in Gaborone, Botswana
| Totals | All N (%) |
Cases 85 (%) |
Controls 190 (%) |
p | |
|---|---|---|---|---|---|
| Baseline CD4 cell counts classifications (cells/μL) | 115 | ||||
| Mild Immunosuppression (>350) | 80 (69·6) | 28 (63·6) | 52 (73·2) | 0·04 | |
| Advanced (200–349) | 11 (9·6) | 2 (4·6) | 9 (12·7) | ||
| Severe (<200) | 24 (20·9) | 14 (31·8) | 10 (14·1) | ||
| Absolute CD4 cell counts | 115 | 44 | 71 | ||
| Mean (SD) | 679 (544) | 691 (628) | 673 (489) | 0·86 | |
| Duration of clinic attendance | 275 | ||||
| Number with CD4 measures | 115 | 44 | 71 | ||
| Duration in days (SD) | 1489 (1260) | 406(604) | 21601082 | <0·01 | |
| Number without CD4 measures | 160 | 41 | 119 | ||
| Duration in days (SD) | 1044 (1000) | 157 (312) | 1350 (973) | <0·01 | |
| Viral load | 275 | ||||
| # with baseline viral load | 94 | 42 | 52 | ||
| Mean (SD) baseline viral load (in logs) | 5·10 (0·75) | 5·33 (0.70) | 4.92 (0·74) | <0·01 | |
| # without baseline viral load | 181 | 43 | 138 | ||
| WHO staging of HIV infection | 249 | ||||
| I and II | 101 (40·6) | 17 (27·9) | 84 (44·7) | 0·02 | |
| III and IV | 148 (59·4) | 44 (72·1) | 104 (55·3) | ||
| Patient on ART | 275 | ||||
| Yes | 208 (75·6) | 24 (28·2) | 184 (96·8) | <0·01 | |
| No | 67 (24·4) | 61 (71·8) | 6 (3·2) | ||
| Patient not on ART (cells/μL) | 62 | ||||
| Mild Immunosuppression (>350) | 56 (90·3) | 51(89·5) | 5(100·0) | 1·00 | |
| Advanced (200–350) | 2 (3·2) | 2 (3·5) | 0(0·0) | ||
| Severe (< 200) | 4 (6·5) | 4 (7·0) | 0(0·0) | ||
| Length of enrollment | 275 | 85 | 190 | ||
| Mean days (SD) | 1325 (1936) | 594 (2965) | 1653 (1086) | <0·01 | |
| Duration enrolled at Clinic | 275 | ||||
| 1 visit | 33 (12·0) | 31 (36·5) | 2 (1·1) | <0·01 | |
| < 6 months | 32 (11·6) | 24 (28·2) | 8 (4·2) | ||
| > 6 months | 210 (76·4) | 30 (35·3) | 180 (94·7) |