Video 1. Open-field movements shown by an uninjured naïve rat (Supplementary to Figure 1 and Experimental Procedures).
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DOI: 10.7554/eLife.18146.008
Rats are placed in a 50 cm diameter Plexiglas cylinder and videotaped for 3 min every fortnight. See Supplementary Figure 1—figure supplement 2 for scoring system. During swing, forepaw digits are extended. Joint movements in the forelimb are smooth and linear. Forepaws are placed slightly medial to the shoulders and the loading response in stance phase is normal, i.e. stance initiated with a single placing movement with immediate weight bearing. When rearing without wall contact, the rats regulate their balance fully through the hind-paws and tail; distal forelimbs are held parallel to the floor. During swing, hindpaws are not raised above the lowest point of the belly. Tail twitches are not seen.