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. 2016 Oct 20;1(17):e89829. doi: 10.1172/jci.insight.89829

Figure 3. Immune infiltration in HPV-positive and -negative head and neck squamous cell carcinoma (HNSCC).

Figure 3

(A) Relative T cell infiltration score (TIS), immune cell infiltration score (IIS), CD8+ T cell infiltration, and Treg infiltration between HPV-negative and -positive squamous cell tumors. (B) Relative expression of immune cell–derived cytotoxic effectors granzyme A, granzyme B, perforin, and their composite effect quantified by their cytolytic (CYT) score between HPV-negative and -positive squamous cell tumors. (C) Relative expression of PD-L1 and CTLA-4 between HPV-negative and -positive squamous cell tumors. (D) Relative median expression of killer cell immunoglobulin-like receptor (KIR) inhibitory genes, KIR2DL1 and KIR2DL3, in HPV-positive and -negative tumors. All box-and-whisker plots represent values within the interquartile range (IQR) (boxes) and 1.5 × IQR (whiskers). All P values for significance (<0.05) represent comparisons via 2-tailed t tests. n = 280.