Figure 4. Pan-cancer immune infiltration analysis.

(A) Relative median immune infiltration across the 10 most immune-infiltrated tumors in increasing order including HPV-positive and -negative HNSCC tumors. (B) Correlations between IFN-γ expression scores and median T cell infiltration score (TIS) across the 10 most immune-infiltrated cancer types including HPV-positive and -negative head and neck squamous cell carcinoma (HNSCC) tumors. (C) Relative median Treg infiltration across the 10 most immune-infiltrated tumors in increasing order including HPV-positive and -negative HNSCC tumors. (D) Relative median Treg/CD8⁺ T cell infiltration ratio across the 10 most immune-infiltrated tumors in increasing order including HPV-positive and -negative HNSCC tumors. (E) Relative median CD56^dim NK cell infiltration across the 10 most immune-infiltrated tumors in increasing order including HPV-positive and -negative HNSCC tumors. All box-and-whisker plots represent values within the interquartile range (IQR) (boxes) and 1.5 × IQR (whiskers). Outliers are plotted as values > 1.5 × IQR (circles).